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Pinning down NuMA [復制鏈接]

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樓主
發表于 2009-3-5 23:45 |只看該作者 |倒序瀏覽 |打印
Macara/Macmillan; j$ S/ F& D( I  S  }

, w, _) @! g% T( DMuch to their surprise, Ian Macara and colleagues (University of Virginia School of Medicine, Charlottesville, VA) have ended up studying not spindle rotation, but spindle construction.
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. b! F) K0 A: iTheir protein of interest, LGN, is the human counterpart of the Drosophila protein Partner of inscuteable (Pins), which helps localize the apical determinant Inscuteable (Insc). Du et al. figured that they could study LGN-mediated spindle rotation using mammalian epithelia, as in these cells the prometaphase spindle rotates to reach its final metaphase orientation. But instead they found that LGN is needed for the construction of the spindle.Overexpression of LGN appears to disrupt microtubule attachment to spindle poles, whereas a lowering of LGN levels using RNAi results in the formation of multiple poles. Thus, LGN may inhibit spindle pole formation, perhaps via an interaction with NuMA that Du et al. detect using multiple methods. NuMA is normally transported to spindle poles where it anchors and focuses microtubules. How LGN might affect this process is unknown, but the entry of LGN into the nucleus at the end of prophase (when the nuclear envelope breaks down) may restrict spindles such that they form only two poles.
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7 t* _4 ~9 B# }# G  oDu, Q., et al. 2001. Nat. Cell Biol. 3:1069–1075.(Spindles go haywire when there is too mu)

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沙發
發表于 2015-6-27 14:38 |只看該作者
這年頭,分不好賺啊  

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藤椅
發表于 2015-7-10 11:10 |只看該作者
希瑞干細胞
ips是誘導多能干細胞induced pluripotent stem cells iPS

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板凳
發表于 2015-7-13 17:10 |只看該作者
干細胞之家微信公眾號
好 好帖 很好帖 確實好帖 少見的好帖  

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報紙
發表于 2015-7-28 13:35 |只看該作者
這貼子你會收藏嗎  

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地板
發表于 2015-8-17 14:18 |只看該作者
呵呵 高高實在是高~~~~~  

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發表于 2015-8-20 22:56 |只看該作者
間充質干細胞

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發表于 2015-8-30 23:23 |只看該作者
希望大家都有好運  

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發表于 2015-10-9 09:10 |只看該作者
我該不會是最后一個頂的吧  

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發表于 2015-11-11 12:40 |只看該作者
嘿嘿......哈哈......呵呵.....喲~呼  
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